SS-31 (also known as Elamipretide) is a mitochondrion-targeted tetrapeptide that selectively binds to cardiolipin on the inner mitochondrial membrane. It has attracted growing interest in research focused on mitochondrial dysfunction, oxidative stress, and age-related diseases.
Studies have shown that SS-31 stabilizes mitochondrial cristae structure, reduces electron leakage, and restores ATP synthesis efficiency. It also scavenges reactive oxygen species (ROS) and prevents mitochondrial permeability transition pore (mPTP) opening. It may also play a role in cardiomyopathy protection, neuroprotection, kidney disease research, and sarcopenia.
Mitochondrial cristae stabilization and cardiolipin binding
ROS scavenging and oxidative stress reduction
ATP synthesis restoration and bioenergetic improvement
Cardiovascular and heart failure research
Neuroprotection and age-related mitochondrial decline