NAD+ (Nicotinamide Adenine Dinucleotide) is a essential coenzyme found in all living cells, playing a critical role in cellular energy metabolism and redox reactions. It has attracted growing interest in research focused on aging, mitochondrial health, and cellular repair mechanisms.
Studies have shown that NAD+ serves as a substrate for key enzymes including sirtuins, PARPs, and CD38, influencing DNA repair, gene expression, and inflammatory pathways. Declining NAD+ levels are associated with aging and metabolic dysfunction. It may also play a role in oxidative stress reduction, circadian rhythm regulation, and protection against age-related decline.
Sirtuin activation and longevity pathways
Mitochondrial function and ATP production
DNA repair and genomic stability
PARP activation and cellular stress responses
Aging research and metabolic health