Melanotan II (also known as Melanotan-2 or MT-2) is a synthetic analogue of alpha-melanocyte-stimulating hormone (α-MSH) with non-selective melanocortin receptor activity. It has attracted growing interest in research focused on skin pigmentation, sexual function, and appetite regulation.
Studies have shown that Melanotan II activates melanocortin receptors (MC1R, MC3R, MC4R, and MC5R), stimulating eumelanin production for UV-independent tanning, while also influencing erectile function and satiety pathways. It may also play a role in libido enhancement, neuroprotection, and modulation of inflammatory responses.
MC1R activation and photoprotective tanning
MC4R-mediated appetite suppression and weight regulation
Erectile dysfunction and sexual health research
Neuroprotective and anti-inflammatory pathways
Erythropoietic protoporphyria (EPP) studies