Mazdutide (also known as IBI362) is a dual agonist of the glucagon-like peptide-1 receptor (GLP-1R) and glucagon receptor (GCGR). It has attracted growing interest in research focused on metabolic health, weight management, and non-alcoholic fatty liver disease (NAFLD).
Studies have shown that Mazdutide activates GLP-1 and glucagon signaling pathways, which synergistically enhance energy expenditure, promote lipid oxidation, suppress appetite, and improve glycemic control. It may also play a role in hepatic fat reduction, insulin sensitivity enhancement, and cardiovascular risk modulation.
Dual GLP-1/GCGR agonism and metabolic regulation
Body weight reduction and obesity treatment
Glucose homeostasis and type 2 diabetes management
Hepatic steatosis resolution and NAFLD/NASH research
Energy expenditure and lipid metabolism