KPV is a tripeptide derived from alpha-melanocyte-stimulating hormone (α-MSH), specifically the C-terminal fragment. It has attracted growing interest in research focused on anti-inflammatory effects, gut health, and immune modulation.
Studies have shown that KPV exerts potent anti-inflammatory activity by inhibiting NF-κB activation and reducing pro-inflammatory cytokine production such as TNF-α, IL-1β, and IL-6. It also promotes wound healing and protects epithelial barrier function. It may also play a role in inflammatory bowel disease (IBD) research, skin inflammation reduction, and treatment of chronic inflammatory conditions.
NF-κB inhibition and anti-inflammatory signaling
Gastrointestinal health and IBD research
Epithelial barrier protection and wound healing
Skin inflammation and dermatological studies
Immune modulation and cytokine regulation