5-Amino-1MQ is a small-molecule inhibitor of nicotinamide N-methyltransferase (NNMT). It has attracted growing interest in research focused on metabolic health, adipose tissue regulation, and cellular energy metabolism.
Studies have shown that 5-Amino-1MQ inhibits NNMT activity, leading to increased intracellular nicotinamide adenine dinucleotide (NAD⁺) levels, enhanced SIRT1 activation, and improved metabolic efficiency. It may also play a role in fat reduction, glucose homeostasis, and anti-inflammatory pathways without central nervous system stimulation.
NNMT inhibition and NAD⁺ elevation
Adipose tissue remodeling and fat mass reduction
Insulin sensitivity and glucose metabolism
SIRT1 activation and cellular energy balance
Metabolic syndrome and obesity research